Trinnpris angis for ikke-patenterte legemidler, hvor det foreligger generisk konkurranse mellom legemidler som Direktoratet for medisinske produkter har vurdert som likeverdige.
Modafinil excels at what it had been at first intended to do: it promotes wakefulness, increases alertness, and enhances psychological function inside a sleep-deprived point out.
modafinil will minimize the extent or effect of levoketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.
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Obstructive sleep apnea, a dysfunction that takes place when your respiratory stops and starts while you snooze since your airway receives blocked
Stone et al (2002) showed the α1A adrenergic receptor antagonist WB4101 plus the α1D antagonist BMY7378 had very little impact on the increase in motor action due to modafinil, but terazosin, which blocks α1A, α1D, and α1B receptors noticeably attenuated this outcome. Also, modafinil had incredibly modest results on gross motion in α1B receptor knockout mice.
Jenner et al (2000) checked out the neuroprotective and anti-parkinsonian consequences of modafinil in monkeys dealt with with MPTP. In a single review they located the MPTP induced parkinsonism indications might be improved with modafinil eleven months right after MPTP administration. In a second research they observed that modafinil administration with MPTP was unable to stop Preliminary locomotor consequences of MPTP, but was ready to revive locomotor action within two weeks.
fedratinib will increase the degree or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Modify dose of medicine which might be CYP3A4 substrates as important.
etravirine will reduce the level or impact of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Sebban C, Tesolin-Decros B, et al. Contrasting EEG profiles elicited by antipsychotic brokers within the prefrontal cortex from the conscious rat: antagonism of the results of clozapine by modafinil.
Clopidogrel efficacy might be lowered by prescription drugs that inhibit CYP2C19. Inhibition of platelet aggregation by clopidogrel is completely resulting from an active metabolite. Clopidogrel is metabolized to this active metabolite in part by CYP2C19. .
It is additionally sometimes termed multiorgan hypersensitivity. This can be a reaction which will have an effect on numerous areas of the body, which include your liver, kidneys, and heart. Quit having modafinil click here and acquire assistance right away When you have any of the subsequent indicators of a serious allergic reaction.
Avoid or substitute An additional drug for these remedies when attainable. Consider for loss of therapeutic impact if medication have to be coadministered.
ceritinib will raise the stage or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.